UniProt functional annotation for Q5JS13



	UniProt functional annotation for Q5JS13

UniProt code: Q5JS13.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}.

Subunit: Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC. {ECO:0000269|PubMed:10747847}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:10889189}. Cell membrane {ECO:0000269|PubMed:10889189}. Note=Associates with membranes through the PH domain.

Tissue specificity: Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus. {ECO:0000269|PubMed:10747847, ECO:0000269|PubMed:10889189}.

Domain: The PH domain mediates binding to membranes. It is required for efficient GEF activity.

Sequence caution: Sequence=AAH19329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA20808.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Guanine nucleotide exchange factor (GEF) for the small GTPase RALA. May be involved in cytoskeletal organization (By similarity). Guanine nucleotide exchange factor for. {ECO:0000250, ECO:0000269\|PubMed:10747847, ECO:0000269\|PubMed:10889189}.


Subunit:		Interacts with the SH3 domains of GRB2, NCK1, PLCG1 and SRC. {ECO:0000269\|PubMed:10747847}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:10889189}. Cell membrane {ECO:0000269\|PubMed:10889189}. Note=Associates with membranes through the PH domain.
Tissue specificity:		Widely expressed (at protein level). Isoform 2 is expressed in brain, colon, kidney, pancreas, prostate, skeletal muscle, small intestine, testis, thymus and uterus. Isoform 1 is expressed at high levels in heart and testis and at lower levels in brain, pancreas, skeletal muscle, small intestine and thymus. {ECO:0000269\|PubMed:10747847, ECO:0000269\|PubMed:10889189}.
Domain:		The PH domain mediates binding to membranes. It is required for efficient GEF activity.
Sequence caution:		Sequence=AAH19329.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BAA20808.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};