PDBsum entry 3qwr

Protein binding/cytokine

PDB id: 3qwr

Contents

Protein chains

295 a.a.

141 a.a.

91 a.a.

Ligands

NAG-NAG-BMA-MAN

Waters ×1

PDB id:

3qwr

Name:

Protein binding/cytokine

Title:

Crystal structure of il-23 in complex with an adnectin

Structure:

Interleukin-12 subunit beta. Chain: a. Synonym: il-12b, cytotoxic lymphocyte maturation factor 40 kda subunit, clmf p40, il-12 subunit p40, nk cell stimulatory factor chain 2, nksf2. Engineered: yes. Interleukin-23 subunit alpha. Chain: b. Synonym: il-23 subunit alpha, il-23-a, interleukin-23 subunit p19,

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: il12b, nksf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: il23a, sgrf, unq2498/pro5798. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

3.25Å R-factor: 0.235 R-free: 0.264

Authors:

A.Wei,S.Sheriff

Key ref:

V.Ramamurthy et al. (2012). Structures of adnectin/protein complexes reveal an expanded binding footprint. Structure, 20, 259-269. PubMed id: 22325775

Date:

28-Feb-11 Release date: 01-Feb-12

Protein chain

P29460  (IL12B_HUMAN) -  Interleukin-12 subunit beta from Homo sapiens

Seq: 328 a.a.

Struc: 295 a.a.

Protein chain

Q9NPF7  (IL23A_HUMAN) -  Interleukin-23 subunit alpha from Homo sapiens

Seq: 189 a.a.

Struc: 141 a.a.

Protein chain

No UniProt id for this chain

Struc: 91 a.a.

Structure 20:259-269 (2012)

PubMed id: 22325775

Structures of adnectin/protein complexes reveal an expanded binding footprint.

V.Ramamurthy, S.R.Krystek, A.Bush, A.Wei, S.L.Emanuel, R.Das Gupta, A.Janjua, L.Cheng, M.Murdock, B.Abramczyk, D.Cohen, Z.Lin, P.Morin, J.H.Davis, M.Dabritz, D.C.McLaughlin, K.A.Russo, G.Chao, M.C.Wright, V.A.Jenny, L.J.Engle, E.Furfine, S.Sheriff.

ABSTRACT

No abstract given.