PDBsum entry 3qup

Transferase/transferase inhibitor

PDB id: 3qup

Contents

Protein chain

241 a.a.

Ligands

LUN

Waters ×76

PDB id:

3qup

Name:

Transferase/transferase inhibitor

Title:

Inhibitor bound structure of the kinase domain of the murine receptor tyrosine kinase tyro3 (sky)

Structure:

Tyrosine-protein kinase receptor tyro3. Chain: a. Fragment: kinase domain. Synonym: etk2/tyro3, tk19-2, tyrosine-protein kinase dtk, tyrosine- protein kinase rse. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: tyro3, dtk, rse. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.90Å R-factor: 0.239 R-free: 0.262

Authors:

J.F.Ohren

Key ref:

N.A.Powell et al. (2012). Novel and selective spiroindoline-based inhibitors of Sky kinase. Bioorg Med Chem Lett, 22, 190-193. PubMed id: 22119469

Date:

24-Feb-11 Release date: 21-Dec-11

Protein chain

P55144  (TYRO3_MOUSE) -  Tyrosine-protein kinase receptor TYRO3 from Mus musculus

Seq: 880 a.a.

Struc: 241 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Bioorg Med Chem Lett 22:190-193 (2012)

PubMed id: 22119469

Novel and selective spiroindoline-based inhibitors of Sky kinase.

N.A.Powell, J.T.Kohrt, K.J.Filipski, M.Kaufman, D.Sheehan, J.E.Edmunds, A.Delaney, Y.Wang, F.Bourbonais, D.Y.Lee, F.Schwende, F.Sun, P.McConnell, C.Catana, H.Chen, J.Ohren, L.A.Perrin.

ABSTRACT

No abstract given.