PDBsum entry 3que

Transferase/transferase inhibitor

PDB id: 3que

Contents

Protein chain

343 a.a.

Ligands

BOG ×2

3FF

Waters ×14

PDB id:

3que

Name:

Transferase/transferase inhibitor

Title:

Human p38 map kinase in complex with skepinone-l

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, csbp, map kinase mxi2, max-interacting protein 2, mitogen-activated protein kinase p38 alpha, map kinase p38 alpha, sapk2a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.70Å R-factor: 0.230 R-free: 0.311

Authors:

C.Gruetter,S.Mayer-Wrangowski,A.Richters,D.Rauh

Key ref:

S.C.Koeberle et al. (2011). Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol, 8, 141-143. PubMed id: 22198732

Date:

23-Feb-11 Release date: 18-Jan-12

Protein chain

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 343 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Nat Chem Biol 8:141-143 (2011)

PubMed id: 22198732

Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.

S.C.Koeberle, J.Romir, S.Fischer, A.Koeberle, V.Schattel, W.Albrecht, C.Grütter, O.Werz, D.Rauh, T.Stehle, S.A.Laufer.

ABSTRACT

No abstract given.