PDBsum entry 3qr1

Hydrolase

PDB id

3qr1

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Contents

			Protein chains

					781 a.a.

			Metals

					_CA ×2

			Waters ×38

PDB id:

3qr1

Links

Name:

Hydrolase

Title:

Crystal structure of l. Pealei plc21

Structure:

PhospholipasE C-beta (plc-beta). Chain: a, d. Other_details: loligo pealei plc21

Source:

Loligo pealei. Longfin inshore squid. Organism_taxid: 6621. Tissue: retina

Resolution:

3.20Å

R-factor:

0.216

R-free:

0.258

Authors:

A.M.Lyon,K.C.Suddala,J.K.Northup,J.J.G.Tesmer

Key ref:

A.M.Lyon et al. (2011). An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Nat Struct Biol, 18, 999-1005. PubMed id: 21822282

Date:

16-Feb-11

Release date:

10-Aug-11

PROCHECK

	Headers

	References

Protein chains

Q9NBA8 (Q9NBA8_DORPE) - 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase from Doryteuthis pealeii

Seq: Struc:

Seq: Struc:

Seq: Struc:					1127 a.a. 781 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.1.4.11 - phosphoinositide phospholipase C.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

myo-Inositol Phosphate Metabolism

Reaction:

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H⁺

1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)	+	H2O	=	1D-myo-inositol 1,4,5-trisphosphate	+	1,2-diacyl-sn-glycerol	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Nat Struct Biol 18:999-1005 (2011)
PubMed id: 21822282

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation.
A.M.Lyon, V.M.Tesmer, V.D.Dhamsania, D.M.Thal, J.Gutierrez, S.Chowdhury, K.C.Suddala, J.K.Northup, J.J.Tesmer.

ABSTRACT

No abstract given.