PDBsum entry 3qmz

Motor protein

PDB id

3qmz

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Contents

			Protein chains

					2136 a.a.


					216 a.a.

PDB id:

3qmz

Links

Name:

Motor protein

Title:

Crystal structure of the cytoplasmic dynein heavy chain motor domain

Structure:

Cytoplasmic dynein heavy chain. Chain: a, b. Fragment: unp residues 1364-4092. Engineered: yes. Glutathione-s-transferase. Chain: t, s. Engineered: yes

Source:

Saccharomyces cerevisiae. Organism_taxid: 4932. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932. Schistosoma japonicum. Organism_taxid: 6182. Expression_system_taxid: 4932

Resolution:

6.00Å

R-factor:

0.430

R-free:

0.430

Authors:

C.Cho,A.P.Carter,L.Jin,R.D.Vale

Key ref:

A.P.Carter et al. (2011). Crystal structure of the dynein motor domain. Science, 331, 1159-1165. PubMed id: 21330489

Date:

07-Feb-11

Release date:

16-Mar-11

PROCHECK

	Headers

	References

Protein chains

P36022 (DYHC_YEAST) - Dynein heavy chain, cytoplasmic from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					4092 a.a. 2136 a.a.*

Protein chains

P08515 (GST26_SCHJA) - Glutathione S-transferase class-mu 26 kDa isozyme from Schistosoma japonicum

Seq: Struc:					218 a.a. 216 a.a.

Key:

PfamA domain

Secondary structure

* PDB and UniProt seqs differ at 9 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

Chains T, S: E.C.2.5.1.18 - glutathione transferase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

RX + glutathione = an S-substituted glutathione + a halide anion + H⁺

RX	+	glutathione	=	S-substituted glutathione	+	halide anion	+	H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

	Science 331:1159-1165 (2011)
PubMed id: 21330489

Crystal structure of the dynein motor domain.
A.P.Carter, C.Cho, L.Jin, R.D.Vale.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22426545

H.Schmidt, E.S.Gleave, and A.P.Carter (2012).
Insights into dynein motor domain function from a 3.3-Å crystal structure.

Nat Struct Mol Biol, 19, 492.

PDB codes:

4ai6 4akg 4akh 4aki

22551707

P.Höök, and R.Vallee (2012).
Dynein dynamics.

Nat Struct Mol Biol, 19, 467-469.

22373868

R.B.Vallee, R.J.McKenney, and K.M.Ori-McKenney (2012).
Multiple modes of cytoplasmic dynein regulation.

Nat Cell Biol, 14, 224-230.

22398446

T.Kon, T.Oyama, R.Shimo-Kon, K.Imamula, T.Shima, K.Sutoh, and G.Kurisu (2012).
The 2.8 Å crystal structure of the dynein motor domain.

Nature, 484, 345-350.

PDB codes:

3vkg 3vkh

22231401

W.Qiu, N.D.Derr, B.S.Goodman, E.Villa, D.Wu, W.Shih, and S.L.Reck-Peterson (2012).
Dynein achieves processive motion using both stochastic and coordinated stepping.

Nat Struct Mol Biol, 19, 193-200.

21385703

J.A.Spudich (2011).
Biochemistry. Molecular motors, beauty in complexity.

Science, 331, 1143-1144.

21968990

K.Nasmyth (2011).
Cohesin: a catenase with separate entry and exit gates?

Nat Cell Biol, 13, 1170-1177.

21642959

N.Billington, and J.R.Sellers (2011).
Dynein struts its stuff.

Nat Struct Mol Biol, 18, 635-636.

21602819

T.Kon, K.Sutoh, and G.Kurisu (2011).
X-ray structure of a functional full-length dynein motor domain.

Nat Struct Mol Biol, 18, 638-642.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.