PDBsum entry 3qiw

Immune system

PDB id: 3qiw

Contents

Protein chains

179 a.a.

165 a.a.

178 a.a.

238 a.a.

13 a.a.

Ligands

NAG ×2

PDB id:

3qiw

Name:

Immune system

Title:

Crystal structure of the 226 tcr in complex with mcc-p5e/i-ek

Structure:

H-2 class ii histocompatibility antigen, e-k alpha chain. Chain: a. Fragment: unp residues 26-217. Engineered: yes. Mhc class ii h2-ia-beta chain. Chain: b. Fragment: unp residues 29-224. Engineered: yes. Tcr 226 alpha chain.

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: h2-eb1. Manduca sexta. Carolina sphinx,hornblower,tobacco hawkmoth,tomato hornworm.

Resolution:

3.30Å R-factor: 0.215 R-free: 0.267

Authors:

A.C.Kruse,L.K.Ely,E.W.Newell,M.M.Davis,K.C.Garcia

Key ref:

E.W.Newell et al. (2011). Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k). J Immunol, 186, 5823-5832. PubMed id: 21490152

Date:

27-Jan-11 Release date: 27-Apr-11

Protein chain

P04224  (HA22_MOUSE) -  H-2 class II histocompatibility antigen, E-K alpha chain from Mus musculus

Seq: 255 a.a.

Struc: 179 a.a.

Protein chain

P04230  (HB21_MOUSE) -  H-2 class II histocompatibility antigen, E-B beta chain from Mus musculus

Seq: 264 a.a.

Struc: 165 a.a.*

Protein chain

No UniProt id for this chain

Struc: 178 a.a.

Protein chain

No UniProt id for this chain

Struc: 238 a.a.

Protein chain

P00039  (CYC_MANSE) -  Cytochrome c from Manduca sexta

Seq: 108 a.a.

Struc: 13 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

J Immunol 186:5823-5832 (2011)

PubMed id: 21490152

Structural basis of specificity and cross-reactivity in T cell receptors specific for cytochrome c-I-E(k).

E.W.Newell, L.K.Ely, A.C.Kruse, P.A.Reay, S.N.Rodriguez, A.E.Lin, M.S.Kuhns, K.C.Garcia, M.M.Davis.

ABSTRACT

No abstract given.