PDBsum entry 3qhz

Immune system

PDB id

3qhz

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Contents

			Protein chains

					222 a.a. *


					216 a.a. *

			Waters ×939

* Residue conservation analysis

PDB id:

3qhz

Links

Name:

Immune system

Title:

Crystal structure of human anti-influenza fab 2d1

Structure:

Human monoclonal antibody del2d1, fab heavy chain. Chain: h, i. Fragment: fab heavy chain. Engineered: yes. Human monoclonal antibody del2d1, fab light chain. Chain: l, m. Fragment: fab light chain. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: immunoglobulin gamma. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f. Gene: immunoglobulin lambda.

Resolution:

1.55Å

R-factor:

0.181

R-free:

0.206

Authors:

D.C.Ekiert,I.A.Wilson

Key ref:

J.C.Krause et al. (2011). An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody. Mbio, 2, e00345. PubMed id: 21304166

Date:

26-Jan-11

Release date:

16-Feb-11

PROCHECK

	Headers

	References

Protein chains

No UniProt id for this chain

Struc:					222 a.a.

Protein chains

No UniProt id for this chain

Struc:					216 a.a.

Key:

Secondary structure

CATH domain

	Mbio 2:e00345 (2011)
PubMed id: 21304166

An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody.
J.C.Krause, D.C.Ekiert, T.M.Tumpey, P.B.Smith, I.A.Wilson, J.E.Crowe.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22982990

D.C.Ekiert, A.K.Kashyap, J.Steel, A.Rubrum, G.Bhabha, R.Khayat, J.H.Lee, M.A.Dillon, R.E.O'Neil, A.M.Faynboym, M.Horowitz, L.Horowitz, A.B.Ward, P.Palese, R.Webby, R.A.Lerner, R.R.Bhatt, and I.A.Wilson (2012).
Cross-neutralization of influenza A viruses mediated by a single antibody loop.

Nature, 489, 526-532.

PDB codes:

4fnk 4fnl 4fp8 4fqr

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.