PDBsum entry 3qfv

Transferase/transferase inhibitor

PDB id: 3qfv

Contents

Protein chains

395 a.a.

Ligands

NM7 ×2

EDO ×3

Metals

_CL ×2

_MG

Waters ×116

PDB id:

3qfv

Name:

Transferase/transferase inhibitor

Title:

Mrck beta in complex with tpca-1

Structure:

Cdc42bpb protein. Chain: a, b. Fragment: unp residues 1-415. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc42bpb, mrck beta. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.65Å R-factor: 0.196 R-free: 0.268

Authors:

T.J.Heikkila,E.Wheatley,D.Crighton,E.Schroder,A.Boakes,S.J.Kaye, M.Mezna,L.Pang,M.Rushbrooke,A.Turnbull,M.F.Olson

Key ref:

T.Heikkila et al. (2011). Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. Plos One, 6, e24825. PubMed id: 21949762

Date:

23-Jan-11 Release date: 12-Oct-11

Protein chains

Q9Y5S2  (MRCKB_HUMAN) -  Serine/threonine-protein kinase MRCK beta from Homo sapiens

Seq: 1711 a.a.

Struc: 395 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Plos One 6:e24825 (2011)

PubMed id: 21949762

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion.

T.Heikkila, E.Wheatley, D.Crighton, E.Schroder, A.Boakes, S.J.Kaye, M.Mezna, L.Pang, M.Rushbrooke, A.Turnbull, M.F.Olson.

ABSTRACT

No abstract given.