PDBsum entry 3qeu

Immune system

PDB id

3qeu

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Contents

			Protein chains

					202 a.a.


					243 a.a.

			Ligands

					GOL ×2

			Metals

					_LI

			Waters ×498

PDB id:

3qeu

Links

Name:

Immune system

Title:

The crystal structure of tcr dmf5

Structure:

Dmf5 alpha chain. Chain: d, a. Engineered: yes. Dmf5 beta chain. Chain: e, b. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.09Å

R-factor:

0.209

R-free:

0.266

Authors:

O.Y.Borbulevych,S.M.Santhanagopolan,B.M.Baker

Key ref:

O.Y.Borbulevych et al. (2011). TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms. J Immunol, 187, 2453-2463. PubMed id: 21795600

Date:

20-Jan-11

Release date:

06-Jul-11

PROCHECK

	Headers

	References

Protein chains

P01848 (TCA_HUMAN) - T cell receptor alpha chain constant from Homo sapiens

Seq: Struc:					140 a.a. 202 a.a.*

Protein chains

No UniProt id for this chain

Struc:					243 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 1 residue position (black cross)

	J Immunol 187:2453-2463 (2011)
PubMed id: 21795600

TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms.
O.Y.Borbulevych, S.M.Santhanagopolan, M.Hossain, B.M.Baker.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

22918468

A.K.Sewell (2012).
Why must T cells be cross-reactive?

Nat Rev Immunol, 12, 669-677.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.