spacer
spacer

PDBsum entry 3qeq
Go to PDB code: 
protein ligands Protein-protein interface(s) links
Immune system PDB id
3qeq

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
275 a.a.
100 a.a.
194 a.a.
243 a.a.
Ligands
ALA-ALA-GLY-ILE-
GLY-ILE-LEU-THR-
VAL
Waters ×103
PDB id:
3qeq
Name: Immune system
Title: The complex between tcr dmf4 and human class i mhc hla-a2 with the bound mart-1(27-35) nonameric peptide
Structure: Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a. Synonym: mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b. Synonym: beta-2-microglobulin form pi 5.3. Engineered: yes. Mart-1(27-35) peptide.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.
Resolution:
2.59Å     R-factor:   0.218     R-free:   0.269
Authors: O.Y.Borbulevych,B.M.Baker
Key ref: O.Y.Borbulevych et al. (2011). TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms. J Immunol, 187, 2453-2463. PubMed id: 21795600
Date:
20-Jan-11     Release date:   06-Jul-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens
Seq:
Struc: 		365 a.a.
275 a.a.*
Protein chain
Pfam   ArchSchema ?
P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens
Seq:
Struc: 		119 a.a.
100 a.a.*
Protein chain
Pfam   ArchSchema ?
P01848  (TCA_HUMAN) -  T cell receptor alpha chain constant from Homo sapiens
Seq:
Struc: 		140 a.a.
194 a.a.*
Protein chain
No UniProt id for this chain
Struc: 243 a.a.
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 21 residue positions (black crosses)

 

 
J Immunol 187:2453-2463 (2011)
PubMed id: 21795600  
 
 
TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms.
O.Y.Borbulevych, S.M.Santhanagopolan, M.Hossain, B.M.Baker.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22918468 A.K.Sewell (2012).
Why must T cells be cross-reactive?
  Nat Rev Immunol, 12, 669-677.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

spacer
spacer