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PDBsum entry 3qdz
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Hydrolase/hydrolase receptor
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PDB id
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3qdz
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PDB id:
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| Name: |
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Hydrolase/hydrolase receptor
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Title:
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Crystal structure of the human thrombin mutant d102n in complex with the extracellular fragment of human par4.
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Structure:
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Thrombin light chain. Chain: a, c. Synonym: coagulation factor ii, activation peptide fragment 1, activation peptide fragment 2, thrombin light chain, thrombin heavy chain. Engineered: yes. Thrombin heavy chain. Chain: b, d. Synonym: coagulation factor ii, activation peptide fragment 1,
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: f2. Expressed in: mesocricetus auratus. Expression_system_taxid: 10036. Expression_system_cell_line: bhk. Gene: f2rl3, par4. Expression_system_cell_line: bhk
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Resolution:
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2.80Å
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R-factor:
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0.304
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R-free:
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0.364
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Authors:
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P.Gandhi,Z.Chen,E.Appelbaum,F.Zapata,E.Di Cera
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Key ref:
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P.S.Gandhi
et al.
(2011).
Structural basis of thrombin-Protease-Receptor intera.
Iubmb life,
63,
375.
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Date:
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19-Jan-11
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Release date:
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29-Jun-11
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PROCHECK
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Headers
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References
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Enzyme class:
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Chains A, B, C, D:
E.C.3.4.21.5
- thrombin.
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Reaction:
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Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.
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Links
