PDBsum entry 3qcu

Immune system

PDB id: 3qcu

Contents

Protein chains

219 a.a.

218 a.a.

Ligands

NKN ×2

Waters ×284

PDB id:

3qcu

Name:

Immune system

Title:

Crystal structure of the lt3015 antibody fab fragment in complex with lysophosphatidic acid (14:0)

Structure:

Lt3015 antibody fab fragment, heavy chain. Chain: h, i. Engineered: yes. Lt3015 antibody fab fragment, light chain. Chain: l, m. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dkfzp686p15220. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Gene: igkc. Expression_system_taxid: 10029

Resolution:

1.98Å R-factor: 0.223 R-free: 0.252

Authors:

J.K.Fleming,J.M.Wojciak,M.-A.Campbell,T.Huxford

Key ref:

J.K.Fleming et al. (2011). Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody. J Mol Biol, 408, 462-476. PubMed id: 21392506

Date:

17-Jan-11 Release date: 30-Mar-11

Protein chains

Q6N089  (Q6N089_HUMAN) -  Ig-like domain-containing protein from Homo sapiens

Seq: 472 a.a.

Struc: 219 a.a.*

Protein chains

P01834  (IGKC_HUMAN) -  Immunoglobulin kappa constant from Homo sapiens

Seq: 107 a.a.

Struc: 218 a.a.

* PDB and UniProt seqs differ at 63 residue positions (black crosses)

J Mol Biol 408:462-476 (2011)

PubMed id: 21392506

Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.

J.K.Fleming, J.M.Wojciak, M.A.Campbell, T.Huxford.

ABSTRACT

No abstract given.