PDBsum entry 3qci

Hydrolase/hydrolase inhibitor

PDB id: 3qci

Contents

Protein chain

285 a.a.

Ligands

NX3

Waters ×45

PDB id:

3qci

Name:

Hydrolase/hydrolase inhibitor

Title:

Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with n-[(3-aminophenyl)sulfonyl]-3-[(3,4-dichlorobenzyl) sulfanyl]thiophene-2-carboxamide

Structure:

Receptor-type tyrosine-protein phosphatase gamma. Chain: a. Synonym: protein-tyrosine phosphatase gamma, r-ptp-gamma. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpg, ptprg. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.27Å R-factor: 0.240 R-free: 0.289

Authors:

S.Sheriff

Key ref:

S.Sheriff et al. (2011). Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop. J Med Chem, 54, 6548-6562. PubMed id: 21882820

Date:

16-Jan-11 Release date: 28-Dec-11

Protein chain

P23470  (PTPRG_HUMAN) -  Receptor-type tyrosine-protein phosphatase gamma from Homo sapiens

Seq: 1445 a.a.

Struc: 285 a.a.

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

J Med Chem 54:6548-6562 (2011)

PubMed id: 21882820

Small molecule receptor protein tyrosine phosphatase γ (RPTPγ) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop.

S.Sheriff, B.R.Beno, W.Zhai, W.A.Kostich, P.A.McDonnell, K.Kish, V.Goldfarb, M.Gao, S.E.Kiefer, J.Yanchunas, Y.Huang, S.Shi, S.Zhu, C.Dzierba, J.Bronson, J.E.Macor, K.K.Appiah, R.S.Westphal, J.O'Connell, S.W.Gerritz.

ABSTRACT

No abstract given.