PDBsum entry 3qbn

Transferase/transferase inhibitor

PDB id: 3qbn

Contents

Protein chain

250 a.a.

Ligands

E9Z

PDB id:

3qbn

Name:

Transferase/transferase inhibitor

Title:

Structure of human aurora a in complex with a diaminopyrimidine

Structure:

Serine/threonine-protein kinase 6. Chain: a. Fragment: unp residues 124-403. Synonym: aurora kinase a, aurora/ipl1-related kinase 1, ark-1, aurora-related kinase 1, hark1, breast tumor-amplified kinase, serine/threonine-protein kinase 15, serine/threonine-protein kinase aurora-a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: aurka, aik, ark1, aura, btak, stk15, stk6. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

3.50Å R-factor: 0.257 R-free: 0.334

Authors:

C.Gruetter,J.R.Simard,D.Rauh

Key ref:

S.Tückmantel et al. (2011). Identification of Ustilago maydis Aurora kinase as a novel antifungal target. Acs Chem Biol, 6, 926-933. PubMed id: 21671622 DOI: 10.1021/cb200112y

Date:

13-Jan-11 Release date: 18-Jan-12

Protein chain

O14965  (AURKA_HUMAN) -  Aurora kinase A from Homo sapiens

Seq: 403 a.a.

Struc: 250 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1021/cb200112y

Acs Chem Biol 6:926-933 (2011)

PubMed id: 21671622

Identification of Ustilago maydis Aurora kinase as a novel antifungal target.

S.Tückmantel, J.N.Greul, P.Janning, A.Brockmeyer, C.Grütter, J.R.Simard, O.Gutbrod, M.E.Beck, K.Tietjen, D.Rauh, P.H.Schreier.

ABSTRACT

No abstract given.