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UniProt functional annotation for Q99598 | ||
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| UniProt code: Q99598. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. {ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:21552258}. |
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| Subunit: | |
Ring-shaped heterooctamer of six TSN and two TSNAX subunits. Interacts with GOLGA3, TSNAXIP1, SUN1 and AKAP9. Interacts with the homodimeric form of C1D following gamma-radiation. Interacts with TSN and C1D in a mutually exclusive manner. {ECO:0000269|PubMed:11801738, ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:15919079, ECO:0000269|PubMed:21552258, ECO:0000269|PubMed:9013868}. |
| Subcellular location: | |
Cytoplasm, perinuclear region. Golgi apparatus {ECO:0000250}. Nucleus. Note=Accumulate in the Golgi complex of mid- late pachytene spermatocytes (By similarity). Expressed in the cytoplasm in the presence of TSN. {ECO:0000250}. |
| Ptm: | |
Sumoylated with SUMO1. {ECO:0000269|PubMed:15561718}. |
| Similarity: | |
Belongs to the translin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.