 |
PDBsum entry 3q5i
|
|
|
|
PDB id:
|
 |
|
 |
| Name: |
 |
Transferase
|
 |
|
Title:
|
 |
Crystal structure of pbanka_031420
|
|
Structure:
|
 |
Protein kinase. Chain: a. Engineered: yes
|
|
Source:
|
 |
Plasmodium berghei. Organism_taxid: 5821. Strain: anka. Gene: pb000158.03.0, pbanka_031420. Expressed in: escherichia coli. Expression_system_taxid: 562.
|
|
Resolution:
|
 |
|
2.10Å
|
R-factor:
|
0.197
|
R-free:
|
0.250
|
|
|
Authors:
|
 |
A.K.Wernimont,A.Hutchinson,H.Sullivan,E.Panico,L.Crombet,D.Cossar, A.Hassani,M.Vedadi,C.H.Arrowsmith,A.M.Edwards,C.Bountra,J.Weigelt, R.Hui,A.M.Neculai,M.Amani,Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
 |
A.K.Wernimont
et al.
Crystal structure of cdpk1 from plasmodium bergheii, Pbanka_031420.
To be published,
.
|
 |
|
Date:
|
 |
|
28-Dec-10
|
Release date:
|
01-Jun-11
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
Headers
|
 |
|
|
References
|
|
|
|
|
|
|
A0A509AHB6
(CDPK1_PLABA) -
Calcium-dependent protein kinase 1 from Plasmodium berghei (strain Anka)
|
|
|
|
Seq: Struc:
|
 |
 |
 |
523 a.a.
470 a.a.*
|
|
|
|
|
|
|
|
|
 |
 |
|
|
Key: |
 |
 |
Secondary structure |
 |
 |
CATH domain |
 |
|
*
PDB and UniProt seqs differ
at 9 residue positions (black
crosses)
|
|
|
|
|
 |
|
|
 |
 |
 |
 |
Enzyme class:
|
 |
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
|
|
 |
 |
 |
 |
 |
Reaction:
|
 |
|
1.
|
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
|
|
2.
|
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
|
|
 |
 |
 |
 |
 |
L-seryl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-seryl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
|
+
|
ADP
|
+
|
H(+)
|
|
 |
 |
 |
 |
 |
L-threonyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-threonyl-[protein]
Bound ligand (Het Group name = )
matches with 81.25% similarity
|
+
|
ADP
|
+
|
H(+)
|
|
 |
 |
 |
 |
 |
 |
 |
 |
 |
 |
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
 |
');
}
}
 |