PDBsum entry 3q3g

Immune system/cell adhesion

PDB id: 3q3g

Contents

Protein chains

220 a.a.

224 a.a.

189 a.a.

Ligands

EDO ×25

GOL ×11

PEG

Metals

_NA ×3

_CL ×5

_CA ×4

Waters ×320

PDB id:

3q3g

Name:

Immune system/cell adhesion

Title:

Crystal structure of a-domain in complex with antibody

Structure:

Antibody light chain. Chain: c, a, f, j. Antibody heavy chain. Chain: d, b, h, k. Integrin alpha-m. Chain: g, e, i, l. Fragment: unp residues 148-337. Synonym: cd11 antigen-like family member b, cr-3 alpha chain, cell surface glycoprotein mac-1 subunit alpha, leukocyte adhesion receptor

Source:

Mus musculus. Organism_taxid: 10090. Homo sapiens. Human. Organism_taxid: 9606. Gene: itgam, cd11b, cr3a. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.70Å R-factor: 0.213 R-free: 0.244

Authors:

B.Mahalingam,J.P.Xiong,M.A.Arnaout

Key ref:

B.Mahalingam et al. (2011). Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol, 187, 6393-6401. PubMed id: 22095715

Date:

21-Dec-10 Release date: 30-Nov-11

Protein chains

No UniProt id for this chain

Struc: 220 a.a.

Protein chains

No UniProt id for this chain

Struc: 224 a.a.

Protein chains

P11215  (ITAM_HUMAN) -  Integrin alpha-M from Homo sapiens

Seq: 1152 a.a.

Struc: 189 a.a.

J Immunol 187:6393-6401 (2011)

PubMed id: 22095715

Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design.

B.Mahalingam, K.Ajroud, J.L.Alonso, S.Anand, B.D.Adair, A.L.Horenstein, F.Malavasi, J.P.Xiong, M.A.Arnaout.

ABSTRACT

No abstract given.