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UniProt functional annotation for Q8N6C8 | ||
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| UniProt code: Q8N6C8. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Acts as soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF-alpha production by monocytes. {ECO:0000269|PubMed:21559424, ECO:0000269|PubMed:24085305}. |
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| Subcellular location: | |
Secreted {ECO:0000305}. |
| Tissue specificity: | |
Detected in B-cells, and at lower levels in natural killer (NK) cells. Detected in peripheral blood monocytes and lung. {ECO:0000269|PubMed:9278324, ECO:0000269|PubMed:9548455}. |
| Ptm: | |
N-glycosylation is required for ligand binding. {ECO:0000269|PubMed:24085305}. |
Annotations taken from UniProtKB at the EBI.