PDBsum entry 3pyy

Transferase

PDB id: 3pyy

Contents

Protein chain

265 a.a.

Ligands

SO4 ×3

STI ×2

3YY ×2

2PE

GOL

Waters ×215

PDB id:

3pyy

Name:

Transferase

Title:

Discovery and characterization of a cell-permeable, small-moleculE C- abl kinase activator that binds to the myristoyl binding site

Structure:

Tyrosine-protein kinase abl1. Chain: a, b. Fragment: unp residues 266-549. Synonym: abelson murine leukemia viral oncogene homolog 1,abelson tyrosine-protein kinase 1,proto-oncogenE C-abl,p150. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: abl1, abl, jtk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

1.85Å R-factor: 0.189 R-free: 0.204

Authors:

J.Yang,N.Campobasso,M.P.Biju,K.Fisher,X.Q.Pan,J.Cottom,S.Galbraith, T.Ho,H.Zhang,X.Hong,P.Ward,G.Hofmann,B.Siegfried

Key ref:

J.Yang et al. (2011). Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol, 18, 177-186. PubMed id: 21338916

Date:

13-Dec-10 Release date: 09-Mar-11

Protein chains

P00519  (ABL1_HUMAN) -  Tyrosine-protein kinase ABL1 from Homo sapiens

Seq: 1130 a.a.

Struc: 265 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Chem Biol 18:177-186 (2011)

PubMed id: 21338916

Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site.

J.Yang, N.Campobasso, M.P.Biju, K.Fisher, X.Q.Pan, J.Cottom, S.Galbraith, T.Ho, H.Zhang, X.Hong, P.Ward, G.Hofmann, B.Siegfried, F.Zappacosta, Y.Washio, P.Cao, J.Qu, S.Bertrand, D.Y.Wang, M.S.Head, H.Li, S.Moores, Z.Lai, K.Johanson, G.Burton, C.Erickson-Miller, G.Simpson, P.Tummino, R.A.Copeland, A.Oliff.

ABSTRACT

No abstract given.