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PDBsum entry 3py0
Go to PDB code:
Transferase/transferase inhibitor
PDB id
3py0
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Contents
Protein chain
294 a.a.
*
Ligands
EDO
PO4
SU9
Waters
×170
*
Residue conservation analysis
PDB id:
3py0
Links
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CATH
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PDBSWS
PDBePISA
ProSAT
Name:
Transferase/transferase inhibitor
Title:
Cdk2 in complex with inhibitor su9516
Structure:
Cell division protein kinase 2. Chain: a. Synonym: cdk2, p33 protein kinase. Engineered: yes
Source:
Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.75Å
R-factor:
0.212
R-free:
0.260
Authors:
S.Betzi,R.Alam,E.Schonbrunn
Key ref:
S.Betzi et al. (2011). Discovery of a potential allosteric ligand binding site in CDK2.
Acs Chem Biol
,
6
, 492-501.
PubMed id:
21291269
Date:
10-Dec-10
Release date:
16-Feb-11
PROCHECK
Headers
References
Protein chain
?
P24941
(CDK2_HUMAN) - Cyclin-dependent kinase 2 from Homo sapiens
Seq:
Struc:
298 a.a.
294 a.a.
Key:
PfamA domain
Secondary structure
CATH domain
Enzyme reactions
Enzyme class:
E.C.2.7.11.22
- cyclin-dependent kinase.
[IntEnz]
[ExPASy]
[KEGG]
[BRENDA]
Reaction:
1.
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H
+
2.
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H
+
L-seryl-[protein]
+
ATP
=
O-phospho-L-seryl-[protein]
+
ADP
+
H(+)
L-threonyl-[protein]
+
ATP
=
O-phospho-L-threonyl-[protein]
+
ADP
+
H(+)
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
reference
Acs Chem Biol
6
:492-501 (2011)
PubMed id:
21291269
Discovery of a potential allosteric ligand binding site in CDK2.
S.Betzi,
R.Alam,
M.Martin,
D.J.Lubbers,
H.Han,
S.R.Jakkaraj,
G.I.Georg,
E.Schönbrunn.
ABSTRACT
No abstract given.
Links
