UniProt functional annotation for P16621

UniProt code: P16621.

Organism: Drosophila melanogaster (Fruit fly).
Taxonomy: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
 
Function: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). It controls motor axon guidance. {ECO:0000269|PubMed:2554325, ECO:0000269|PubMed:8598047}.
 
Catalytic activity: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. {ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:2554325}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Selectively expressed in a subset of axons and pioneer neurons in the embryo. {ECO:0000269|PubMed:8598047}.
Similarity: Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. {ECO:0000305}.
Similarity: Contains 9 fibronectin type-III domains. {ECO:0000255|PROSITE-ProRule:PRU00316}.
Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.
Similarity: Contains 2 tyrosine-protein phosphatase domains. {ECO:0000255|PROSITE-ProRule:PRU00160}.
Sequence caution: Sequence=AAK93409.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.