PDBsum entry 3pxj

Hydrolase

PDB id: 3pxj

Contents

Protein chains

199 a.a.

187 a.a.

Waters ×138

PDB id:

3pxj

Name:

Hydrolase

Title:

Tandem ig repeats of dlar

Structure:

Tyrosine-protein phosphatase lar. Chain: a, b, c, d. Fragment: ig domains 1 and 2 (unp residues 32-237). Synonym: protein-tyrosine-phosphate phosphohydrolase, dlar. Engineered: yes

Source:

Drosophila melanogaster. Fruit fly. Organism_taxid: 7227. Gene: lar, cg10443. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.30Å R-factor: 0.225 R-free: 0.261

Authors:

B.H.Biersmith,S.Bouyain

Key ref:

B.H.Biersmith et al. (2011). The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation. J Mol Biol, 408, 616-627. PubMed id: 21402080

Date:

10-Dec-10 Release date: 23-Mar-11

Protein chains

P16621  (LAR_DROME) -  Tyrosine-protein phosphatase Lar from Drosophila melanogaster

Seq: 2029 a.a.

Struc: 199 a.a.

Protein chains

P16621  (LAR_DROME) -  Tyrosine-protein phosphatase Lar from Drosophila melanogaster

Seq: 2029 a.a.

Struc: 187 a.a.

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

J Mol Biol 408:616-627 (2011)

PubMed id: 21402080

The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.

B.H.Biersmith, M.Hammel, E.R.Geisbrecht, S.Bouyain.

ABSTRACT

No abstract given.