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UniProt functional annotation for A2A8L5 | ||
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| UniProt code: A2A8L5. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity). {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000255|PROSITE- ProRule:PRU10044}; |
| Subunit: | |
Interacts with GRIP1. Interacts with PPFIA1, PPFIA2 and PPFIA3. Interacts with PTPRF. {ECO:0000250}. |
| Subcellular location: | |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
| Tissue specificity: | |
Expressed in the cell of the T lineage but not in cells of any other hemopoietic lineage. {ECO:0000269|PubMed:11241288}. |
| Domain: | |
The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. {ECO:0000250}. |
| Similarity: | |
Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.