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PDBsum entry 3pxh
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protein ligands links
Hydrolase PDB id
3pxh

 

 

 

 

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Contents
Protein chain
197 a.a.
Ligands
SO4 ×2
Waters ×85
PDB id:
3pxh
Name: Hydrolase
Title: Tandem ig domains of tyrosine phosphatase lar
Structure: Receptor-type tyrosine-protein phosphatase f. Chain: a. Fragment: ig domains 1 and 2 (unp residues 30-226). Synonym: leukocyte common antigen related, lar. Engineered: yes
Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: ptprf, lar. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.00Å     R-factor:   0.221     R-free:   0.240
Authors: B.H.Biersmith,S.Bouyain
Key ref: B.H.Biersmith et al. (2011). The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation. J Mol Biol, 408, 616-627. PubMed id: 21402080
Date:
09-Dec-10     Release date:   23-Mar-11    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
A2A8L5  (PTPRF_MOUSE) -  Receptor-type tyrosine-protein phosphatase F from Mus musculus
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1898 a.a.
197 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.1.3.48  - protein-tyrosine-phosphatase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
O-phospho-L-tyrosyl-[protein]
 + H2O
 = L-tyrosyl-[protein]
 + phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    Key reference    
 
 
J Mol Biol 408:616-627 (2011)
PubMed id: 21402080  
 
 
The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.
B.H.Biersmith, M.Hammel, E.R.Geisbrecht, S.Bouyain.
 
  ABSTRACT  
 
No abstract given.

 

 

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