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UniProt functional annotation for Q68D85 | ||
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| UniProt code: Q68D85. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Triggers NCR3-dependent natural killer cell activation. {ECO:0000269|PubMed:19528259}. |
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| Subunit: | |
Monomer. Interacts specifically with NCR3, but not with other natural killer cell-activating receptors, including NCR1, NCR2 and KLRK1. {ECO:0000269|PubMed:19528259, ECO:0000269|PubMed:21422170}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:19528259}; Single-pass type I membrane protein {ECO:0000269|PubMed:19528259}. |
| Tissue specificity: | |
Not detected in any normal tissue tested. Expressed at the surface of several tumor cell lines including T and B-lymphomas, myeloid leukemias, melanomas, carcinomas and large T SV40 antigen- transformed cells (at protein level). {ECO:0000269|PubMed:19528259}. |
| Domain: | |
The C-terminal part is similar to retroviral Gag protein. This putative protein seems to be the result of a fusion between an Ig-like domain-containing protein and a ERV. |
| Sequence caution: | |
Sequence=CAD97811.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.