UniProt functional annotation for P68187



	UniProt functional annotation for P68187

UniProt code: P68187.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system. {ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}.

Catalytic activity: Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1; Evidence={ECO:0000255|HAMAP-Rule:MF_01709, ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217};

Subunit: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}.

Subcellular location: Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01709, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:18456666}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01709, ECO:0000269|PubMed:16079137, ECO:0000269|PubMed:18456666}.

Miscellaneous: Target for inducer exclusion, mediated by the unphosphorylated enzyme III of the phosphotransferase system for glucose and resulting in the inhibition of maltose transport. {ECO:0000269|PubMed:2250006}.

Miscellaneous: Acts as a repressor of mal genes. In absence of maltose, the C-terminus of MalK interacts with MalT, then MalT becomes inactive and the mal genes are not activated. In presence of maltose, MalK is tightly associated with the MalFG complex and has no affinity for MalT. {ECO:0000269|PubMed:9822819}.

Similarity: Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. {ECO:0000255|HAMAP-Rule:MF_01709}.

Sequence caution: Sequence=CAA23582.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system. {ECO:0000269\|PubMed:2026607, ECO:0000269\|PubMed:2155217}.


Catalytic activity:		Reaction=ATP + D-maltose(out) + H2O = ADP + D-maltose(in) + H(+) + phosphate; Xref=Rhea:RHEA:22132, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17306, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.5.2.1; Evidence={ECO:0000255\|HAMAP-Rule:MF_01709, ECO:0000269\|PubMed:2026607, ECO:0000269\|PubMed:2155217};
Subunit:		The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269\|PubMed:18456666, ECO:0000269\|PubMed:2026607, ECO:0000269\|PubMed:2155217}.
Subcellular location:		Cell inner membrane {ECO:0000255\|HAMAP- Rule:MF_01709, ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:18456666}; Peripheral membrane protein {ECO:0000255\|HAMAP-Rule:MF_01709, ECO:0000269\|PubMed:16079137, ECO:0000269\|PubMed:18456666}.
Miscellaneous:		Target for inducer exclusion, mediated by the unphosphorylated enzyme III of the phosphotransferase system for glucose and resulting in the inhibition of maltose transport. {ECO:0000269\|PubMed:2250006}.
Miscellaneous:		Acts as a repressor of mal genes. In absence of maltose, the C-terminus of MalK interacts with MalT, then MalT becomes inactive and the mal genes are not activated. In presence of maltose, MalK is tightly associated with the MalFG complex and has no affinity for MalT. {ECO:0000269\|PubMed:9822819}.
Similarity:		Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. {ECO:0000255\|HAMAP-Rule:MF_01709}.
Sequence caution:		Sequence=CAA23582.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};