UniProt functional annotation for P02916



	UniProt functional annotation for P02916

UniProt code: P02916.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}.

Subunit: The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269|PubMed:10809785, ECO:0000269|PubMed:18456666, ECO:0000269|PubMed:2026607, ECO:0000269|PubMed:2155217}.

Subcellular location: Cell inner membrane {ECO:0000269|PubMed:18456666}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:18456666}; Periplasmic side {ECO:0000269|PubMed:18456666}. Note=A substantial portion of it protrudes into the periplasmic space; inserts in an SRP- and Sec-dependent, YidC-independent fashion into the membrane.

Miscellaneous: When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed, except for the Gly-407. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter.

Similarity: Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Probably responsible for the translocation of the substrate across the membrane. {ECO:0000269\|PubMed:2026607, ECO:0000269\|PubMed:2155217}.


Subunit:		The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalF) and a solute-binding protein (MalE). Protein stability and stable complex formation require YidC. {ECO:0000269\|PubMed:10809785, ECO:0000269\|PubMed:18456666, ECO:0000269\|PubMed:2026607, ECO:0000269\|PubMed:2155217}.
Subcellular location:		Cell inner membrane {ECO:0000269\|PubMed:18456666}; Multi-pass membrane protein {ECO:0000255\|PROSITE-ProRule:PRU00441, ECO:0000269\|PubMed:18456666}; Periplasmic side {ECO:0000269\|PubMed:18456666}. Note=A substantial portion of it protrudes into the periplasmic space; inserts in an SRP- and Sec-dependent, YidC-independent fashion into the membrane.
Miscellaneous:		When MalF EAA loop mutations are made concomitantly with MalG EAA loop mutations, a complete loss of transport and complex formation is observed, except for the Gly-407. This suggests that the MalF-MalG interaction may be important for the proper assembly and also for the correct function of the transporter.
Similarity:		Belongs to the binding-protein-dependent transport system permease family. MalFG subfamily. {ECO:0000305}.