PDBsum entry 3ptb

Hydrolase (serine proteinase)

PDB id: 3ptb

Contents

Protein chain

223 a.a.

Ligands

BEN

Metals

_CA

Waters ×62

References listed in PDB file

Key reference

Title

The geometry of the reactive site and of the peptide groups in trypsin, Trypsinogen and its complexes with inhibitors

Authors

M.Marquart, J.Walter, J.Deisenhofer, W.Bode, R.Huber.

Ref.

Acta Crystallogr ,Sect B, 1983, 39, 480.

Secondary reference #1

Title

Structural studies on the pancreatic trypsin inhibitor-Trypsin complex and its free components. Structure and function relationships in serine protease inhibition and catalysis

Authors

W.Bode, P.Schwager, R.Huber.

Ref.

Miami Winter Symp, 1976, 11, 43.

Secondary reference #2

Title

The refined crystal structure of bovine beta-Trypsin at 1.8 angstroms resolution. I. Crystallization, Data collection and application of patterson search techniques

Authors

H.Fehlhammer, W.Bode.

Ref.

J Mol Biol, 1975, 98, 683.

Secondary reference #3

Title

The refined crystal structure of bovine beta-Trypsin at 1.8 a resolution. Ii. Crystallographic refinement, Calcium binding site, Benzamidine binding site and active site at ph 7.0.

Authors

W.Bode, P.Schwager.

Ref.

J Mol Biol, 1975, 98, 693-717. [DOI no: 10.1016/S0022-2836(75)80005-2]

PubMed id

512

Figure 4.
FiG. 4. Stereo pair of the calcium-bindng loop including the calcium ion and internal water molecules.

Figure 7.
Fro. 7. Stereo pair of the region aroun the salt bridge between the benzamidine and Asp189 in benzamidine-inhibited trpsin (a) and side chain of LyslS(I) an Asp189 in he trysin- inhibitor complex (b), both in complex orientation.

The above figures are reproduced from the cited reference with permission from Elsevier

Secondary reference #4

Title

The single calcium-Binding site of crystallin bovin beta-Trypsin.

Authors

W.Bode, P.Schwager.

Ref.

FEBS Lett, 1975, 56, 139-143. [DOI no: 10.1016/0014-5793(75)80128-1]

PubMed id

1157929