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UniProt functional annotation for P23615 | ||
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| UniProt code: P23615. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability. {ECO:0000269|PubMed:12934008, ECO:0000269|PubMed:15531585, ECO:0000269|PubMed:16455495, ECO:0000269|PubMed:9450930}. |
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| Subunit: | |
Interacts with CTR9. {ECO:0000269|PubMed:15531585}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:2201908}. Note=Colocalizes with RNA polymerase II on chromatin. Recruited to the active transcribed loci. |
| Miscellaneous: | |
Present with 8890 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}. |
| Similarity: | |
Belongs to the SPT6 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.