UniProt functional annotation for Q6TQR6

UniProt code: Q6TQR6.

Organism:		Crimean-Congo hemorrhagic fever virus (strain Nigeria/IbAr10200/1970) (CCHFV).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Nairoviridae; Orthonairovirus.
Function:		Displays RNA-directed RNA polymerase, deubiquitinating and deISGylase activities. RNA-dependent RNA polymerase is responsible for replication and transcription of the viral RNA genome. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent innate immunity. {ECO:0000269|PubMed:18078692}.
Catalytic activity:		Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76- residue protein attached to proteins as an intracellular targeting signal).; EC=3.4.19.12;
Catalytic activity:		Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
Domain:		The OTU domain is responsible for the deubiquitinating and deISGylation activities of Nsp2. {ECO:0000305}.
Similarity:		Belongs to the nairovirus RNA polymerase family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.