 |
PDBsum entry 3prm
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Hydrolase/hydrolase
|
PDB id
|
|
|
|
3prm
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Hydrolase/hydrolase
|
|
|
Title:
|
|
Structural analysis of a viral otu domain protease from the crimean- congo hemorrhagic fever virus in complex with human ubiquitin
|
|
Structure:
|
|
RNA-directed RNA polymerase l. Chain: a, c. Synonym: protein l,large structural protein,replicase,transcriptase. Ec: 3.4.19.12,3.4.22.-,3.1.-.-,2.7.7.48. Engineered: yes. Polyubiquitin-b (fragment). Chain: b, d. Engineered: yes
|
|
Source:
|
|
Crimean-congo hemorrhagic fever virus. Organism_taxid: 11593. Strain: ibar10200. Expressed in: escherichia coli. Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606. Gene: ubb.
|
|
Resolution:
|
|
|
2.30Å
|
R-factor:
|
0.208
|
R-free:
|
0.267
|
|
|
Authors:
|
|
G.C.Capodagli,M.A.Mckercher,E.A.Baker,E.M.Masters,J.S.Brunzelle, S.D.Pegan
|
|
Key ref:
|
|
G.C.Capodagli
et al.
(2011).
Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin.
J Virol,
85,
3621-3630.
PubMed id:
|
|
|
Date:
|
|
|
30-Nov-10
|
Release date:
|
26-Jan-11
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class 2:
|
|
Chains A, C:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
|
|
|
|
|
|
|
Reaction:
|
|
RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
|
|
|
|
|
|
RNA(n)
|
+
|
ribonucleoside 5'-triphosphate
|
=
|
RNA(n+1)
|
+
|
diphosphate
|
|
|
|
|
|
|
|
|
|
Enzyme class 3:
|
|
Chains A, C:
E.C.3.1.-.-
|
|
|
|
|
|
|
Enzyme class 4:
|
|
Chains A, C:
E.C.3.4.19.12
- ubiquitinyl hydrolase 1.
|
|
|
|
|
|
|
Reaction:
|
|
Thiol-dependent hydrolysis of ester, thiolester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
|
|
|
|
|
|
Enzyme class 5:
|
|
Chains A, C:
E.C.3.4.22.-
- ?????
|
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
|
J Virol
85:3621-3630
(2011)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Structural analysis of a viral ovarian tumor domain protease from the Crimean-Congo hemorrhagic fever virus in complex with covalently bonded ubiquitin.
|
|
G.C.Capodagli,
M.A.McKercher,
E.A.Baker,
E.M.Masters,
J.S.Brunzelle,
S.D.Pegan.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
J.D.Licchesi,
J.Mieszczanek,
T.E.Mevissen,
T.J.Rutherford,
M.Akutsu,
S.Virdee,
F.El Oualid,
J.W.Chin,
H.Ovaa,
M.Bienz,
and
D.Komander
(2012).
An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains.
|
| |
Nat Struct Mol Biol,
19,
62-71.
|
|
|
PDB code:
|
|
|
|
|
|
|
|
R.Wiener,
X.Zhang,
T.Wang,
and
C.Wolberger
(2012).
The mechanism of OTUB1-mediated inhibition of ubiquitination.
|
| |
Nature,
483,
618-622.
|
|
|
PDB codes:
|
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
|
|
|
Links
