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UniProt functional annotation for Q8AYD0 | ||
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| UniProt code: Q8AYD0. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. {ECO:0000269|PubMed:21269602}. |
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| Subcellular location: | |
Cell junction {ECO:0000250|UniProtKB:P33151}. Cell membrane {ECO:0000250|UniProtKB:P33151}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P33151}. |
| Domain: | |
Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain. {ECO:0000269|PubMed:21269602}. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:21269602}. |
| Ptm: | |
O-glycosylated. {ECO:0000269|PubMed:21269602}. |
Annotations taken from UniProtKB at the EBI.