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PDBsum entry 3pma

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protein ligands metals Protein-protein interface(s) links
Hydrolase/hydrolase inhibitor PDB id
3pma

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
29 a.a.
238 a.a.
259 a.a.
Ligands
GU4-YYJ ×2
CIT ×2
Metals
_NA ×2
Waters ×253
PDB id:
3pma
Name: Hydrolase/hydrolase inhibitor
Title: 2.2 angstrom crystal structure of the complex between bovine thrombin and sucrose octasulfate
Structure: Thrombin light chain. Chain: a, c. Fragment: bovine thrombin light chain residues 336-364. Thrombin heavy chain. Chain: b, d. Ec: 3.4.21.5
Source: Bos taurus. Bovine,cow,domestic cattle,domestic cow. Organism_taxid: 9913. Organism_taxid: 9913
Resolution:
2.20Å     R-factor:   0.206     R-free:   0.245
Authors: H.T.Wright,J.N.Scarsdale,B.J.Desai
Key ref: B.J.Desai et al. (2011). Interaction of thrombin with sucrose octasulfate. Biochemistry, 50, 6973-6982. PubMed id: 21736375
Date:
16-Nov-10     Release date:   20-Jul-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00735  (THRB_BOVIN) -  Prothrombin from Bos taurus
Seq:
Struc:
 
Seq:
Struc:
625 a.a.
29 a.a.
Protein chain
Pfam   ArchSchema ?
P00735  (THRB_BOVIN) -  Prothrombin from Bos taurus
Seq:
Struc:
 
Seq:
Struc:
625 a.a.
238 a.a.
Protein chain
Pfam   ArchSchema ?
P00735  (THRB_BOVIN) -  Prothrombin from Bos taurus
Seq:
Struc:
 
Seq:
Struc:
625 a.a.
259 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D: E.C.3.4.21.5  - thrombin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.

 

 
Biochemistry 50:6973-6982 (2011)
PubMed id: 21736375  
 
 
Interaction of thrombin with sucrose octasulfate.
B.J.Desai, R.S.Boothello, A.Y.Mehta, J.N.Scarsdale, H.T.Wright, U.R.Desai.
 
  ABSTRACT  
 
No abstract given.

 

 

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