PDBsum entry 3pjc

Transferase/transferase inhibitor

PDB id: 3pjc

Contents

Protein chain

286 a.a. *

Ligands

PJC

Waters ×139

* Residue conservation analysis

PDB id:

3pjc

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of jak3 complexed with a potent atp site inhibitor showing high selectivity within the janus kinase family

Structure:

Tyrosine-protein kinase jak3. Chain: a. Fragment: unp residues 812-1124. Synonym: janus kinase 3, jak-3, leukocyte janus kinase, l-jak. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.20Å R-factor: 0.182 R-free: 0.215

Authors:

G.A.Tavares,G.Thoma,H.-G.Zerwes,M.Kroemer

Key ref:

G.Thoma et al. (2011). Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family. J Med Chem, 54, 284-288. PubMed id: 21155605

Date:

09-Nov-10 Release date: 29-Dec-10

Protein chain

P52333  (JAK3_HUMAN) -  Tyrosine-protein kinase JAK3 from Homo sapiens

Seq: 1124 a.a.

Struc: 286 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

J Med Chem 54:284-288 (2011)

PubMed id: 21155605

Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.

G.Thoma, F.Nuninger, R.Falchetto, E.Hermes, G.A.Tavares, E.Vangrevelinghe, H.G.Zerwes.

ABSTRACT

No abstract given.