PDBsum entry 3pg3

Transferase/transferase inhibitor

PDB id: 3pg3

Contents

Protein chain

337 a.a.

Ligands

BOG

DG7

Waters ×99

PDB id:

3pg3

Name:

Transferase/transferase inhibitor

Title:

Human p38 map kinase in complex with rl182

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, csbp, map kinase mxi2, max-interacting protein 2, mitogen-activated protein kinase p38 alpha, map kinase p38 alpha, sapk2a. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.00Å R-factor: 0.221 R-free: 0.261

Authors:

C.Gruetter,J.R.Simard,M.Getlik,D.Rauh

Key ref:

M.Getlik et al. Structure-Based design and synthesis of cell active n-Pyrazole, N-Thiazole urea inhibitors of the map kin p38alpha. To be published, .

Date:

29-Oct-10 Release date: 02-Nov-11

Protein chain

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 337 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site