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PDBsum entry 3pd9
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Membrane protein
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PDB id
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3pd9
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PDB id:
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| Name: |
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Membrane protein
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Title:
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X-ray structure of the ligand-binding core of glua2 in complex with (r)-5-hpca at 2.1 a resolution
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Structure:
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Glutamate receptor 2. Chain: a, b. Fragment: unp residues 413-527, 653-795. Synonym: glur-2, ampa-selective glutamate receptor 2, glur-b, glur- k2, glutamate receptor ionotropic, ampa 2, glua2. Engineered: yes
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Source:
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Rattus norvegicus. Brown rat,rat,rats. Organism_taxid: 10116. Gene: glur2, gria2, rat. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.10Å
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R-factor:
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0.180
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R-free:
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0.233
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Authors:
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K.Frydenvang,J.S.Kastrup
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Key ref:
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K.Frydenvang
et al.
(2010).
Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
J Med Chem,
53,
8354-8361.
PubMed id:
DOI:
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Date:
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22-Oct-10
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Release date:
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29-Dec-10
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PROCHECK
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Headers
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References
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P19491
(GRIA2_RAT) -
Glutamate receptor 2 from Rattus norvegicus
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Seq:
Struc:
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883 a.a.
258 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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DOI no:
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J Med Chem
53:8354-8361
(2010)
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PubMed id:
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Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.
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K.Frydenvang,
D.S.Pickering,
J.R.Greenwood,
N.Krogsgaard-Larsen,
L.Brehm,
B.Nielsen,
S.B.Vogensen,
H.Hald,
J.S.Kastrup,
P.Krogsgaard-Larsen,
R.P.Clausen.
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ABSTRACT
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Links
