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PDBsum entry 3p8h
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Transcription
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PDB id
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3p8h
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Contents |
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* Residue conservation analysis
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PDB id:
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Transcription
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Title:
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Crystal structure of l3mbtl1 (mbt repeat) in complex with a nicotinamide antagonist
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Structure:
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Lethal(3)malignant brain tumor-like protein. Chain: a, b, c. Fragment: unp residues 200-522. Synonym: h-l(3)mbt, h-l(3)mbt protein, l(3)mbt-like, l(3)mbt protein homolog, l3mbtl1. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: kiaa0681, l3mbt, l3mbtl, l3mbtl1. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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2.55Å
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R-factor:
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0.194
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R-free:
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0.242
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Authors:
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R.Lam,J.M.Herold,H.Ouyang,W.Tempel,C.Gao,M.Ravichandran,G.Senisterra, C.Bountra,J.Weigelt,C.H.Arrowsmith,A.M.Edwards,M.Vedadi,D.Kireev, S.V.Frye,P.J.Brown,Structural Genomics Consortium (Sgc)
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Key ref:
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J.M.Herold
et al.
(2011).
Small-molecule ligands of methyl-lysine binding proteins.
J Med Chem,
54,
2504-2511.
PubMed id:
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Date:
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13-Oct-10
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Release date:
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03-Nov-10
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PROCHECK
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Headers
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References
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Q9Y468
(LMBL1_HUMAN) -
Lethal(3)malignant brain tumor-like protein 1 from Homo sapiens
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Seq:
Struc:
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840 a.a.
313 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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J Med Chem
54:2504-2511
(2011)
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PubMed id:
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Small-molecule ligands of methyl-lysine binding proteins.
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J.M.Herold,
T.J.Wigle,
J.L.Norris,
R.Lam,
V.K.Korboukh,
C.Gao,
L.A.Ingerman,
D.B.Kireev,
G.Senisterra,
M.Vedadi,
A.Tripathy,
P.J.Brown,
C.H.Arrowsmith,
J.Jin,
W.P.Janzen,
S.V.Frye.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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C.H.Arrowsmith,
C.Bountra,
P.V.Fish,
K.Lee,
and
M.Schapira
(2012).
Epigenetic protein families: a new frontier for drug discovery.
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Nat Rev Drug Discov,
11,
384-400.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
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Links
