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PDBsum entry 3p5l

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protein ligands metals links
Lyase/inhibitor PDB id
3p5l
Jmol PyMol
Contents
Protein chain
257 a.a.
Ligands
IT5
DMS
Metals
_ZN
Waters ×172
PDB id:
3p5l
Name: Lyase/inhibitor
Title: Human carbonic anhydrase complexed with sodium 4-cyano-4- phenylpiperidine-1-carbodithioate
Structure: Carbonic anhydrase 2. Chain: a. Synonym: carbonate dehydratase ii, carbonic anhydrasE C, ca carbonic anhydrase ii, ca-ii. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
1.50Å     R-factor:   0.167     R-free:   0.190
Authors: M.Aggarwal,R.Mckenna
Key ref: F.Carta et al. (2012). Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chem Commun (Camb), 48, 1868-1870. PubMed id: 22218610 DOI: 10.1039/c2cc16395k
Date:
08-Oct-10     Release date:   19-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2
Seq:
Struc:
260 a.a.
257 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.4.2.1.1  - Carbonic anhydrase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: H2CO3 = CO2 + H2O
H(2)CO(3)
= CO(2)
+ H(2)O
      Cofactor: Zn(2+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   11 terms 
  Biological process     angiotensin-mediated signaling pathway   22 terms 
  Biochemical function     protein binding     6 terms  

 

 
    Added reference    
 
 
DOI no: 10.1039/c2cc16395k Chem Commun (Camb) 48:1868-1870 (2012)
PubMed id: 22218610  
 
 
Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations.
F.Carta, M.Aggarwal, A.Maresca, A.Scozzafava, R.McKenna, C.T.Supuran.
 
  ABSTRACT  
 
No abstract given.

 

 

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