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PDBsum entry 3p4f
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Transcription
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PDB id
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3p4f
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Contents |
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* Residue conservation analysis
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PDB id:
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Transcription
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Title:
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Structural and biochemical insights into mll1 core complex assembly and regulation.
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Structure:
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Wd repeat-containing protein 5. Chain: a. Fragment: unp residues 1-308. Synonym: bmp2-induced 3-kb gene protein. Engineered: yes. Retinoblastoma-binding protein 5. Chain: b. Fragment: unp residues 371-381. Synonym: rbbp-5, retinoblastoma-binding protein rbq-3.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: wdr5, big3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: synthetic peptide (new england peptide). Other_details: synthetic peptide (new england peptide)
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Resolution:
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2.35Å
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R-factor:
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0.197
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R-free:
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0.249
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Authors:
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V.Avdic,P.Zhang,S.Lanouette,A.Groulx,V.Tremblay,J.B.Brunzelle,J.- F.Couture
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Key ref:
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V.Avdic
et al.
(2011).
Structural and biochemical insights into MLL1 core complex assembly.
Structure,
19,
101-108.
PubMed id:
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Date:
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06-Oct-10
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Release date:
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08-Dec-10
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PROCHECK
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Headers
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References
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P61964
(WDR5_HUMAN) -
WD repeat-containing protein 5 from Homo sapiens
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Seq:
Struc:
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334 a.a.
304 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.1.1.43
- Transferred entry: 2.1.1.354.
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Reaction:
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S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone]
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S-adenosyl-L-methionine
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+
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L-lysine-[histone]
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=
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S-adenosyl-L-homocysteine
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+
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N(6)-methyl-L-lysine-[histone]
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Structure
19:101-108
(2011)
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PubMed id:
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Structural and biochemical insights into MLL1 core complex assembly.
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V.Avdic,
P.Zhang,
S.Lanouette,
A.Groulx,
V.Tremblay,
J.Brunzelle,
J.F.Couture.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.Sarvan,
V.Avdic,
V.Tremblay,
C.P.Chaturvedi,
P.Zhang,
S.Lanouette,
A.Blais,
J.S.Brunzelle,
M.Brand,
and
J.F.Couture
(2011).
Crystal structure of the trithorax group protein ASH2L reveals a forkhead-like DNA binding domain.
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Nat Struct Mol Biol,
18,
857-859.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
