PDBsum entry 3p1e

Transcription

PDB id: 3p1e

Contents

Protein chains

114 a.a. *

Ligands

SCN

DMS ×2

Metals

__K

Waters ×179

* Residue conservation analysis

PDB id:

3p1e

Name:

Transcription

Title:

Crystal structure of the bromodomain of human crebbp in complex with dimethyl sulfoxide (dmso)

Structure:

Creb-binding protein. Chain: a, b. Fragment: bromo domain, unp residues 1081-1197. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.80Å R-factor: 0.182 R-free: 0.236

Authors:

P.Filippakopoulos,S.Picaud,I.Feletar,O.Fedorov,J.Muniz,F.Von Delft, C.H.Arrowsmith,A.M.Edwards,J.Weigelt,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)

Key ref:

P.Filippakopoulos et al. Crystal structure of the bromodomain of human crebbp complex with dimethyl sulfoxide (dmso). To be published, .

Date:

30-Sep-10 Release date: 24-Nov-10

Protein chains

Q92793  (CBP_HUMAN) -  CREB-binding protein from Homo sapiens

Seq: 2442 a.a.

Struc: 114 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.3.1.- - ?????
• Enzyme class 2: E.C.2.3.1.48 - histone acetyltransferase.
• Reaction: L-lysyl-[protein] + acetyl-CoA = N₆-acetyl-L-lysyl-[protein] + CoA + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site