spacer
spacer

PDBsum entry 3oyw

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Carbohydrate binding protein PDB id
3oyw
Jmol PyMol
Contents
Protein chain
134 a.a. *
Ligands
TDG ×2
Waters ×66
* Residue conservation analysis
PDB id:
3oyw
Name: Carbohydrate binding protein
Title: Crystal structure of human galectin-1 in complex with thiodigalactoside
Structure: Galectin-1. Chain: a. Synonym: gal-1, lectin galactoside-binding soluble 1, beta- galactoside-binding lectin l-14-i, lactose-binding lectin 1 lectin 1, galaptin, 14 kda lectin, hpl, hbl, putative mapk- protein pm12, 14 kda laminin-binding protein, hlbp14. Engineered: yes. Galectin-1. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lgals1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
Resolution:
2.50Å     R-factor:   0.171     R-free:   0.245
Authors: H.Blanchard,P.M.Collins
Key ref: K.A.Stannard et al. (2010). Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett, 299, 95. PubMed id: 20826047 DOI: 10.1016/j.canlet.2010.08.005
Date:
23-Sep-10     Release date:   03-Nov-10    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P09382  (LEG1_HUMAN) -  Galectin-1
Seq:
Struc:
135 a.a.
134 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   10 terms 
  Biological process     response to isolation stress   17 terms 
  Biochemical function     signal transducer activity     8 terms  

 

 
DOI no: 10.1016/j.canlet.2010.08.005 Cancer Lett 299:95 (2010)
PubMed id: 20826047  
 
 
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.
K.A.Stannard, P.M.Collins, K.Ito, E.M.Sullivan, S.A.Scott, E.Gabutero, I.Darren Grice, P.Low, U.J.Nilsson, H.Leffler, H.Blanchard, S.J.Ralph.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21469926 T.Verschuere, S.De Vleeschouwer, F.Lefranc, R.Kiss, and S.W.Van Gool (2011).
Galectin-1 and immunotherapy for brain cancer.
  Expert Rev Neurother, 11, 533-543.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.

 

spacer

spacer