PDBsum entry 3oyw

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Carbohydrate binding protein PDB id
Jmol PyMol
Protein chain
134 a.a. *
TDG ×2
Waters ×66
* Residue conservation analysis
PDB id:
Name: Carbohydrate binding protein
Title: Crystal structure of human galectin-1 in complex with thiodigalactoside
Structure: Galectin-1. Chain: a. Synonym: gal-1, lectin galactoside-binding soluble 1, beta- galactoside-binding lectin l-14-i, lactose-binding lectin 1 lectin 1, galaptin, 14 kda lectin, hpl, hbl, putative mapk- protein pm12, 14 kda laminin-binding protein, hlbp14. Engineered: yes. Galectin-1. Chain: b.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: lgals1. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
2.50Å     R-factor:   0.171     R-free:   0.245
Authors: H.Blanchard,P.M.Collins
Key ref: K.A.Stannard et al. (2010). Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model. Cancer Lett, 299, 95. PubMed id: 20826047 DOI: 10.1016/j.canlet.2010.08.005
23-Sep-10     Release date:   03-Nov-10    
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Protein chains
Pfam   ArchSchema ?
P09382  (LEG1_HUMAN) -  Galectin-1
135 a.a.
134 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   10 terms 
  Biological process     response to isolation stress   17 terms 
  Biochemical function     signal transducer activity     8 terms  


DOI no: 10.1016/j.canlet.2010.08.005 Cancer Lett 299:95 (2010)
PubMed id: 20826047  
Galectin inhibitory disaccharides promote tumour immunity in a breast cancer model.
K.A.Stannard, P.M.Collins, K.Ito, E.M.Sullivan, S.A.Scott, E.Gabutero, I.Darren Grice, P.Low, U.J.Nilsson, H.Leffler, H.Blanchard, S.J.Ralph.
No abstract given.


Literature references that cite this PDB file's key reference

  PubMed id Reference
21469926 T.Verschuere, S.De Vleeschouwer, F.Lefranc, R.Kiss, and S.W.Van Gool (2011).
Galectin-1 and immunotherapy for brain cancer.
  Expert Rev Neurother, 11, 533-543.  
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