PDBsum entry 3oq3

Cytokine/viral protein

PDB id: 3oq3

Contents

Protein chains

166 a.a.

329 a.a.

Ligands

EDO ×4

ACT ×2

EPE ×2

Metals

_ZN

_CL

Waters ×361

PDB id:

3oq3

Name:

Cytokine/viral protein

Title:

Structural basis of type-i interferon sequestration by a poxvirus decoy receptor

Structure:

Interferon alpha-5. Chain: a. Synonym: ifn-alpha-5. Engineered: yes. Ifn-alpha/beta binding protein c12r. Chain: b. Synonym: interferon alpha/beta receptor, soluble interferon- alpha/beta receptor. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: ifna5. Expressed in: escherichia coli. Expression_system_taxid: 562. Ectromelia virus. Organism_taxid: 265874. Strain: moscow.

Resolution:

2.10Å R-factor: 0.204 R-free: 0.235

Authors:

D.H.Fremont,C.A.Lee,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

D.H.Fremont et al. Structural basis of type-I interferon sequestration b poxvirus decoy receptor. To be published, .

Date:

02-Sep-10 Release date: 18-May-11

Protein chain

P07349  (IFNA5_MOUSE) -  Interferon alpha-5 from Mus musculus

Seq: 189 a.a.

Struc: 166 a.a.

Protein chain

Q9JFS5  (Q9JFS5_9POXV) -  Soluble interferon alpha/beta receptor OPG204 from Ectromelia virus

Seq: 358 a.a.

Struc: 329 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)