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PDBsum entry 3oob
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PDB id:
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Isomerase
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Title:
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Structural and functional insights of directly targeting pin1 by epigallocatechin-3-gallate
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Structure:
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Peptidyl-prolyl cis-trans isomerase nima-interacting 1. Chain: a. Synonym: peptidyl-prolyl cis-trans isomerase pin1, ppiase pin1, rotamase pin1. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pin1. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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1.89Å
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R-factor:
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0.192
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R-free:
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0.232
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Authors:
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D.V.Urusova,J.-H.Shim,D.-J.Kim,S.K.Jung,T.A.Zykova,A.M.Bode,Z.Dong
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Key ref:
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D.V.Urusova
et al.
(2011).
Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
Cancer Prev Res (phila),
4,
1366-1377.
PubMed id:
DOI:
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Date:
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30-Aug-10
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Release date:
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17-Aug-11
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PROCHECK
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Headers
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References
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Q13526
(PIN1_HUMAN) -
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 from Homo sapiens
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Seq:
Struc:
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163 a.a.
146 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.5.2.1.8
- peptidylprolyl isomerase.
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Reaction:
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[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)
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Peptidylproline (omega=180)
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=
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peptidylproline (omega=0)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Cancer Prev Res (phila)
4:1366-1377
(2011)
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PubMed id:
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Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1.
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D.V.Urusova,
J.H.Shim,
D.J.Kim,
S.K.Jung,
T.A.Zykova,
A.Carper,
A.M.Bode,
Z.Dong.
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ABSTRACT
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