 |
PDBsum entry 3olr
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Hydrolase
|
|
|
Title:
|
|
Ptpn22 in complex with consensus phospho-tyrosine peptide 1
|
|
Structure:
|
|
Tyrosine-protein phosphatase non-receptor type 22. Chain: a, b, c, d. Fragment: unp residues 1-294. Synonym: hematopoietic cell protein-tyrosine phosphatase 70z-pep, lymphoid phosphatase, lyp. Engineered: yes. Mutation: yes. Skap2. Chain: e, f, g, h.
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn22, ptpn8. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence is derived from a peptide screen
|
|
Resolution:
|
|
|
2.50Å
|
R-factor:
|
0.162
|
R-free:
|
0.210
|
|
|
Authors:
|
|
X.Yu,J.-P.Sun,S.Zhang,Z.-Y.Zhang
|
|
Key ref:
|
|
X.Yu
et al.
Structure basis of lyp substrate specificity revealed reverse alanine screening and crystallography.
To be published,
.
|
|
|
Date:
|
|
|
26-Aug-10
|
Release date:
|
29-Jun-11
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
Q9Y2R2
(PTN22_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 22 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
807 a.a.
297 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.3.1.3.48
- protein-tyrosine-phosphatase.
|
|
|
|
|
|
|
Reaction:
|
|
O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
|
|
|
|
|
|
O-phospho-L-tyrosyl-[protein]
|
+
|
H2O
|
=
|
L-tyrosyl-[protein]
|
+
|
phosphate
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
