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UniProt functional annotation for O43157 | ||
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| UniProt code: O43157. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
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| Subunit: | |
Monomer, and heterodimer with PLXNB2 after proteolytic processing (PubMed:12533544, PubMed:17916560, PubMed:18411422, PubMed:18275816, PubMed:19843518, PubMed:20877282, PubMed:21912513). Binds RAC1 that has been activated by GTP binding (PubMed:11035813, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interaction with SEMA4D promotes binding of cytoplasmic ligands (PubMed:10520995, PubMed:12198496, PubMed:19843518). Interacts with PLXNA1 (By similarity). Interacts with ARHGEF11 and ARHGEF12 (PubMed:12196628). Interacts with ERBB2 (PubMed:15210733). Interacts with MET (PubMed:12198496, PubMed:15184888). Interacts with MST1R (PubMed:15184888). Interacts with RRAS (PubMed:19843518). Interacts with RHOD (PubMed:17916560). Interacts with RND1 (PubMed:12730235, PubMed:17916560, PubMed:18275816, PubMed:19843518). Interacts with NRP1 and NRP2 (PubMed:10520995). {ECO:0000250|UniProtKB:Q8CJH3, ECO:0000269|PubMed:10520995, ECO:0000269|PubMed:11035813, ECO:0000269|PubMed:12196628, ECO:0000269|PubMed:12198496, ECO:0000269|PubMed:12533544, ECO:0000269|PubMed:12730235, ECO:0000269|PubMed:15184888, ECO:0000269|PubMed:15210733, ECO:0000269|PubMed:17916560, ECO:0000269|PubMed:18275816, ECO:0000269|PubMed:18411422, ECO:0000269|PubMed:19843518, ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:21912513}. |
| Subcellular location: | |
[Isoform 1]: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}. |
| Subcellular location: | |
[Isoform 2]: Secreted {ECO:0000269|PubMed:10520995}. |
| Subcellular location: | |
[Isoform 3]: Secreted {ECO:0000269|PubMed:10520995}. |
| Tissue specificity: | |
Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. {ECO:0000269|PubMed:8570614}. |
| Ptm: | |
Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. {ECO:0000269|PubMed:10520995, ECO:0000269|PubMed:15210733}. |
| Ptm: | |
Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. {ECO:0000269|PubMed:12533544}. |
| Similarity: | |
Belongs to the plexin family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA23703.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.