PDBsum entry 3oky

Signaling protein

PDB id

3oky

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Contents

			Protein chains

					609 a.a. *


					540 a.a. *

			Ligands

					NAG-NAG


					NAG ×6


					GOL ×5

			Waters ×389

* Residue conservation analysis

PDB id:

3oky

Links

Name:

Signaling protein

Title:

Plexin a2 in complex with semaphorin 6a

Structure:

Plexin-a2. Chain: a. Fragment: residues 33-703, extracellular domains 1-4. Synonym: plexin-2, plex 2. Engineered: yes. Putative uncharacterized protein. Chain: b. Fragment: extracellular domains 1-2. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: kiaa0463, plxna2. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Gene: sema6a.

Resolution:

2.20Å

R-factor:

0.192

R-free:

0.230

Authors:

B.J.C.Janssen,R.A.Robinson,C.H.Bell,C.Siebold,E.Y.Jones

Key ref:

B.J.Janssen et al. (2010). Structural basis of semaphorin-plexin signalling. Nature, 467, 1118-1122. PubMed id: 20877282

Date:

25-Aug-10

Release date:

13-Oct-10

PROCHECK

	Headers

	References

Protein chain

P70207 (PLXA2_MOUSE) - Plexin-A2 from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1894 a.a. 609 a.a.

Protein chain

O35464 (SEM6A_MOUSE) - Semaphorin-6A from Mus musculus

Seq: Struc:

Seq: Struc:

Seq: Struc:					1031 a.a. 540 a.a.

Key:

PfamA domain

Secondary structure

CATH domain

	Nature 467:1118-1122 (2010)
PubMed id: 20877282

Structural basis of semaphorin-plexin signalling.
B.J.Janssen, R.A.Robinson, F.Pérez-Brangulí, C.H.Bell, K.J.Mitchell, C.Siebold, E.Y.Jones.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23104057

B.J.Janssen, T.Malinauskas, G.A.Weir, M.Z.Cader, C.Siebold, and E.Y.Jones (2012).
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.

Nat Struct Mol Biol, 19, 1293-1299.

PDB codes:

4gz8 4gz9 4gza

22002224

M.Kim, Z.Y.Sun, K.D.Rand, X.Shi, L.Song, Y.Cheng, A.F.Fahmy, S.Majumdar, G.Ofek, Y.Yang, P.D.Kwong, J.H.Wang, J.R.Engen, G.Wagner, and E.L.Reinherz (2011).
Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization.

Nat Struct Mol Biol, 18, 1235-1243.

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.