PDBsum entry 3ojv

Cytokine/signaling protein

PDB id: 3ojv

Contents

Protein chains

133 a.a.

213 a.a.

Ligands

SGN-IDS-SGN-IDS-SGN-UAP

Waters ×32

PDB id:

3ojv

Name:

Cytokine/signaling protein

Title:

Crystal structure of fgf1 complexed with the ectodomain of fgfr1c exhibiting an ordered ligand specificity-determining betac'-betae loop

Structure:

Heparin-binding growth factor 1. Chain: a, b. Synonym: hbgf-1, acidic fibroblast growth factor, afgf, beta- endothelial cell growth factor, ecgf-beta. Engineered: yes. Basic fibroblast growth factor receptor 1. Chain: c, d. Fragment: fgfr1c. Synonym: bfgf-r-1, fgfr-1, proto-oncogenE C-fgr, fms-like tyrosine

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: fgf1, fgfa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: fgfbr, fgfr1, flg, flt2.

Resolution:

2.60Å R-factor: 0.251 R-free: 0.309

Authors:

A.Beenken,M.Mohammadi

Key ref:

A.Beenken et al. (2012). Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1. J Biol Chem, 287, 3067-3078. PubMed id: 22057274

Date:

23-Aug-10 Release date: 28-Dec-11

Protein chains

P05230  (FGF1_HUMAN) -  Fibroblast growth factor 1 from Homo sapiens

Seq: 155 a.a.

Struc: 133 a.a.

Protein chains

P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens

Seq: 822 a.a.

Struc: 213 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: Chains C, D: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

J Biol Chem 287:3067-3078 (2012)

PubMed id: 22057274

Plasticity in interactions of fibroblast growth factor 1 (FGF1) N terminus with FGF receptors underlies promiscuity of FGF1.

A.Beenken, A.V.Eliseenkova, O.A.Ibrahimi, S.K.Olsen, M.Mohammadi.

ABSTRACT

No abstract given.