UniProt functional annotation for O04197



	UniProt functional annotation for O04197

UniProt code: O04197.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant- pathogen interactions with Pseudomonas syringae and Alternaria brassicicola. {ECO:0000269|PubMed:10810145, ECO:0000269|PubMed:12172031, ECO:0000269|PubMed:12172836, ECO:0000269|PubMed:12244256, ECO:0000269|PubMed:12445118, ECO:0000269|PubMed:12724535, ECO:0000269|PubMed:12805591, ECO:0000269|PubMed:14756769, ECO:0000269|PubMed:9582125}.

Pathway: Protein modification; protein ubiquitination.

Subunit: Component of SCF(COI1) E3 ubiquitin ligase complexes at least composed of ASK1 or ASK2, CUL1, RBX1A or RBX1B and COI1. Interacts with ASK1 and ASK2, but separately, Binds also to ASK11 and ASK12. Interacts with RBCS-1B and HDA6. SCF complexes interact with the COP9 signalosome (CSN). Interacts with TIFY10A. {ECO:0000269|PubMed:12172031, ECO:0000269|PubMed:12445118, ECO:0000269|PubMed:12724535, ECO:0000269|PubMed:14749489, ECO:0000269|PubMed:20927106}.

Domain: The F-box domain is essential for the formation of SFC(COI1) complexes. {ECO:0000269|PubMed:12008900}.

Domain: The Leu-rich domain is involved in the interactions with RBCS- 1B and RPD3B. {ECO:0000269|PubMed:12008900}.

Disruption phenotype: Mutants coi1-1 to coi1-14 are male sterile, insensitive to MeJA and coronatine, and exhibit enhanced resistance to Pseudomonas syringae atropurpurea (coronatine producing strain). Mutant coi1-16 has reduced sensitivity to jasmonate, but is male fertile when grown below 22 degrees Celsius and male sterile otherwise. {ECO:0000269|PubMed:9582125}.

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles in regulating response to jasmonate, and their interactions with the COP9 signalosome (CSN) appear to be important for their activity. Interacts with TIFY10A and inositol pentakisphosphate to form a high-affinity jasmonates coreceptor. Involved in the regulation of plant gene expression during plant- pathogen interactions with Pseudomonas syringae and Alternaria brassicicola. {ECO:0000269\|PubMed:10810145, ECO:0000269\|PubMed:12172031, ECO:0000269\|PubMed:12172836, ECO:0000269\|PubMed:12244256, ECO:0000269\|PubMed:12445118, ECO:0000269\|PubMed:12724535, ECO:0000269\|PubMed:12805591, ECO:0000269\|PubMed:14756769, ECO:0000269\|PubMed:9582125}.


Pathway:		Protein modification; protein ubiquitination.
Subunit:		Component of SCF(COI1) E3 ubiquitin ligase complexes at least composed of ASK1 or ASK2, CUL1, RBX1A or RBX1B and COI1. Interacts with ASK1 and ASK2, but separately, Binds also to ASK11 and ASK12. Interacts with RBCS-1B and HDA6. SCF complexes interact with the COP9 signalosome (CSN). Interacts with TIFY10A. {ECO:0000269\|PubMed:12172031, ECO:0000269\|PubMed:12445118, ECO:0000269\|PubMed:12724535, ECO:0000269\|PubMed:14749489, ECO:0000269\|PubMed:20927106}.
Domain:		The F-box domain is essential for the formation of SFC(COI1) complexes. {ECO:0000269\|PubMed:12008900}.
Domain:		The Leu-rich domain is involved in the interactions with RBCS- 1B and RPD3B. {ECO:0000269\|PubMed:12008900}.
Disruption phenotype:		Mutants coi1-1 to coi1-14 are male sterile, insensitive to MeJA and coronatine, and exhibit enhanced resistance to Pseudomonas syringae atropurpurea (coronatine producing strain). Mutant coi1-16 has reduced sensitivity to jasmonate, but is male fertile when grown below 22 degrees Celsius and male sterile otherwise. {ECO:0000269\|PubMed:9582125}.