PDBsum entry 3oez

Transferase

PDB id: 3oez

Contents

Protein chains

261 a.a.

Ligands

STI ×2

ACT

GOL

Waters ×289

PDB id:

3oez

Name:

Transferase

Title:

Crystal structure of the l317i mutant of the chicken c-src tyrosine kinase domain complexed with imatinib

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b. Fragment: kinase domain. Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes. Mutation: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.40Å R-factor: 0.196 R-free: 0.240

Authors:

R.Boubeva,L.Pernot,R.Perozzo,L.Scapozza

Key ref:

R.Boubeva et al. A single amino-Acid dictates the dynamics of the swit between active and inactive c-Src conformation. To be published, .

Date:

13-Aug-10 Release date: 17-Aug-11

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 261 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site